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Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes

BACKGROUND: Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. However, the roles of KLF4 in hematological malignancies and the mechanisms of action are not fully understood. METHODS: Inducible KLF4-overexpression Jurkat cell line combined wit...

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Detalles Bibliográficos
Autores principales:	Li, Wei, Jiang, Zhiwu, Li, Tianzhong, Wei, Xinru, Zheng, Yi, Wu, Donghai, Yang, Lijian, Chen, Shaohua, Xu, Bing, Zhong, Mei, Jiang, Jue, Hu, Yufeng, Su, Hexiu, Zhang, Minjie, Huang, Xiaojun, Geng, Suxia, Weng, Jianyu, Du, Xin, Liu, Pentao, Li, Yangqiu, Liu, Hudan, Yao, Yao, Li, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350611/ https://www.ncbi.nlm.nih.gov/pubmed/25644173 http://dx.doi.org/10.1186/s12943-014-0285-x

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