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Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study
BACKGROUND: Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk group for developing an insufficient vitamin D status. Socioeconomic, dietary,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350646/ https://www.ncbi.nlm.nih.gov/pubmed/25745506 http://dx.doi.org/10.1186/1743-7075-12-2 |
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author | Jungert, Alexandra Neuhäuser-Berthold, Monika |
author_facet | Jungert, Alexandra Neuhäuser-Berthold, Monika |
author_sort | Jungert, Alexandra |
collection | PubMed |
description | BACKGROUND: Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk group for developing an insufficient vitamin D status. Socioeconomic, dietary, lifestyle and environmental factors are considered as influencing factors, whereupon sex differences in predictors of vitamin D status are rarely investigated. The purpose of this study is to identify the main predictors of serum 25-hydroxyvitamin D(3) [25(OH)D(3)] concentrations in elderly subjects by taking into account potential sex differences. METHODS: This is a cross-sectional study in 162 independently living German elderly aged 66 to 96 years. Serum 25(OH)D(3) concentrations were assessed by an electrochemiluminescence immunoassay. Multiple regression analyses were performed to identify predictors of 25(OH)D(3) concentrations stratified by sex. RESULTS: Median 25(OH)D(3) concentration was 64 nmol/L and none of the subjects had 25(OH)D(3) concentrations < 25 nmol/L. In women, intact parathyroid hormone (iPTH) (β = -0.323), % total body fat (β = -0.208), time spent outdoors (β = 0.328), month of blood sampling (β = 0.229) and intake of vitamin D supplements (β = 0.172) were the predominant predictors of 25(OH)D(3), whereas in men, iPTH (β = -0.254), smoking (β = -0.282), physical activity (β = 0.336) and monthly household net income (β = 0.302) predicted 25(OH)D(3) concentrations. The final regression models accounted for 30% and 32% of the variance in 25(OH)D(3) concentrations in women and men, respectively. CONCLUSION: The findings indicate that 25(OH)D(3) concentrations are influenced by body composition, month of blood sampling, economic factors, lifestyle, supplement intake and iPTH, but may not be associated with age, sex, dietary factors, kidney function and presence of selected chronic diseases in community-dwelling elderly. Furthermore, our results provide evidence for sex-specific determinants of the vitamin D status, which ought to be considered for preventive strategies. |
format | Online Article Text |
id | pubmed-4350646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43506462015-03-06 Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study Jungert, Alexandra Neuhäuser-Berthold, Monika Nutr Metab (Lond) Research BACKGROUND: Considering the suggested link between vitamin D insufficiency and several chronic diseases, attention should be given to approaches for improving vitamin D status. Elderly subjects are regarded as a high-risk group for developing an insufficient vitamin D status. Socioeconomic, dietary, lifestyle and environmental factors are considered as influencing factors, whereupon sex differences in predictors of vitamin D status are rarely investigated. The purpose of this study is to identify the main predictors of serum 25-hydroxyvitamin D(3) [25(OH)D(3)] concentrations in elderly subjects by taking into account potential sex differences. METHODS: This is a cross-sectional study in 162 independently living German elderly aged 66 to 96 years. Serum 25(OH)D(3) concentrations were assessed by an electrochemiluminescence immunoassay. Multiple regression analyses were performed to identify predictors of 25(OH)D(3) concentrations stratified by sex. RESULTS: Median 25(OH)D(3) concentration was 64 nmol/L and none of the subjects had 25(OH)D(3) concentrations < 25 nmol/L. In women, intact parathyroid hormone (iPTH) (β = -0.323), % total body fat (β = -0.208), time spent outdoors (β = 0.328), month of blood sampling (β = 0.229) and intake of vitamin D supplements (β = 0.172) were the predominant predictors of 25(OH)D(3), whereas in men, iPTH (β = -0.254), smoking (β = -0.282), physical activity (β = 0.336) and monthly household net income (β = 0.302) predicted 25(OH)D(3) concentrations. The final regression models accounted for 30% and 32% of the variance in 25(OH)D(3) concentrations in women and men, respectively. CONCLUSION: The findings indicate that 25(OH)D(3) concentrations are influenced by body composition, month of blood sampling, economic factors, lifestyle, supplement intake and iPTH, but may not be associated with age, sex, dietary factors, kidney function and presence of selected chronic diseases in community-dwelling elderly. Furthermore, our results provide evidence for sex-specific determinants of the vitamin D status, which ought to be considered for preventive strategies. BioMed Central 2015-01-14 /pmc/articles/PMC4350646/ /pubmed/25745506 http://dx.doi.org/10.1186/1743-7075-12-2 Text en © Jungert and Neuhäuser-Berthold; licensee BioMed Central. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Jungert, Alexandra Neuhäuser-Berthold, Monika Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study |
title | Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study |
title_full | Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study |
title_fullStr | Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study |
title_full_unstemmed | Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study |
title_short | Sex-specific determinants of serum 25-hydroxyvitamin D(3) concentrations in an elderly German cohort: a cross-sectional study |
title_sort | sex-specific determinants of serum 25-hydroxyvitamin d(3) concentrations in an elderly german cohort: a cross-sectional study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350646/ https://www.ncbi.nlm.nih.gov/pubmed/25745506 http://dx.doi.org/10.1186/1743-7075-12-2 |
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