Crystal structure of 4-{[(naphthalen-2-yl)sulfonyl­amino]­meth­yl}cyclo­hexa­necarb­oxy­lic acid

The title compound, C(18)H(21)NO(4)S, is a new sulfonamide derivative of tranexamic acid. In the crystal, mol­ecules form inversion dimers via O—H⋯O hydrogen bonds involving the carb­oxy­lic acid groups. Hydrogen bonding between the sulfonamide N—H group and the carb­oxy­lic acid O atom assembles th...

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Detalles Bibliográficos
Autores principales: Danish, Muhammad, Tahir, Muhammad Nawaz, Hussain, Asif, Ashfaq, Muhammad, Sadiq, Muhammad Nadeem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Data Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350692/
https://www.ncbi.nlm.nih.gov/pubmed/25844218
http://dx.doi.org/10.1107/S2056989015002054
Descripción
Sumario:The title compound, C(18)H(21)NO(4)S, is a new sulfonamide derivative of tranexamic acid. In the crystal, mol­ecules form inversion dimers via O—H⋯O hydrogen bonds involving the carb­oxy­lic acid groups. Hydrogen bonding between the sulfonamide N—H group and the carb­oxy­lic acid O atom assembles the dimers into thick layers parallel to (100). The naphthalene groups of adjacent layers are arranged in a herring-bone motif. There are C—H⋯π inter­actions between the naphthalene rings of neighbouring layers.

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