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Crystal structure of ethyl 5′′-fluoro-2′′,3-dioxo-6′,7′,8′,8a’-tetra­hydro-2′H,3H,5′H-di­spiro­[benzo[b]thio­phene-2,1′-indol­izine-3′,3′′-indoline]-2′-carboxyl­ate

In the title compound, C(25)H(23)FN(2)O(4)S, the fused piperidine ring of the octa­hydro­indolizine ring system adopts a chair conformation and the five-membered ring has a twisted conformation on the N—C(spiro) bond. The mean planes of the benzo­thio­phene and indoline ring systems are inclined to...

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Detalles Bibliográficos
Autores principales: Raja, R., Govindaraj, J., Suresh, M., Raghunathan, R., SubbiahPandi, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350745/
https://www.ncbi.nlm.nih.gov/pubmed/25844224
http://dx.doi.org/10.1107/S2056989015002121
Descripción
Sumario:In the title compound, C(25)H(23)FN(2)O(4)S, the fused piperidine ring of the octa­hydro­indolizine ring system adopts a chair conformation and the five-membered ring has a twisted conformation on the N—C(spiro) bond. The mean planes of the benzo­thio­phene and indoline ring systems are inclined to the mean plane of the pyrrolidine ring by 83.1 (1) and 84.9 (1)°, respectively, and to each other by 29.37 (17)°. In the crystal, mol­ecules are linked via pairs of N—H⋯O hydrogen bonds, forming inversion dimers with an R (2) (2)(8) ring motif. The dimers are linked via C—H⋯O hydrogen bonds, forming slabs lying parallel to (100). The packing between the slabs features a short [2.734 (2) Å] F⋯F contact.