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Charge Reduction and Thermodynamic Stabilization of Substrate RNAs Inhibit RNA Editing
African trypanosomes cause a parasitic disease known as sleeping sickness. Mitochondrial transcript maturation in these organisms requires a RNA editing reaction that is characterized by the insertion and deletion of U-nucleotides into otherwise non-functional mRNAs. Editing represents an ideal targ...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350841/ https://www.ncbi.nlm.nih.gov/pubmed/25742417 http://dx.doi.org/10.1371/journal.pone.0118940 |