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Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients
Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350869/ https://www.ncbi.nlm.nih.gov/pubmed/25789314 http://dx.doi.org/10.1155/2015/345647 |
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author | Chen, Yu-Chen Xia, Wenqing Feng, Yuan Li, Xiaowei Zhang, Jian Feng, Xu Wang, Cong-Xiao Cai, Yu Wang, Jian Salvi, Richard Teng, Gao-Jun |
author_facet | Chen, Yu-Chen Xia, Wenqing Feng, Yuan Li, Xiaowei Zhang, Jian Feng, Xu Wang, Cong-Xiao Cai, Yu Wang, Jian Salvi, Richard Teng, Gao-Jun |
author_sort | Chen, Yu-Chen |
collection | PubMed |
description | Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients. Materials and Methods. Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning. We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups. Results. Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus. In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus. Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex. Conclusions. These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus. |
format | Online Article Text |
id | pubmed-4350869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43508692015-03-18 Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients Chen, Yu-Chen Xia, Wenqing Feng, Yuan Li, Xiaowei Zhang, Jian Feng, Xu Wang, Cong-Xiao Cai, Yu Wang, Jian Salvi, Richard Teng, Gao-Jun Biomed Res Int Research Article Purpose. Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), to examine the resting-state interhemispheric functional connectivity and its relationships with clinical characteristics in chronic tinnitus patients. Materials and Methods. Twenty-eight chronic tinnitus patients with normal hearing thresholds and 30 age-, sex-, education-, and hearing threshold-matched healthy controls were included in this study and underwent the resting-state fMRI scanning. We computed the VMHC to analyze the interhemispheric functional coordination between homotopic points of the brain in both groups. Results. Compared to the controls, tinnitus patients showed significantly increased VMHC in the middle temporal gyrus, middle frontal gyrus, and superior occipital gyrus. In tinnitus patients, a positive correlation was found between tinnitus duration and VMHC of the uncus. Moreover, correlations between VMHC changes and tinnitus distress were observed in the transverse temporal gyrus, superior temporal pole, precentral gyrus, and calcarine cortex. Conclusions. These results show altered interhemispheric functional connectivity linked with specific tinnitus characteristics in chronic tinnitus patients, which may be implicated in the neuropathophysiology of tinnitus. Hindawi Publishing Corporation 2015 2015-02-19 /pmc/articles/PMC4350869/ /pubmed/25789314 http://dx.doi.org/10.1155/2015/345647 Text en Copyright © 2015 Yu-Chen Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Yu-Chen Xia, Wenqing Feng, Yuan Li, Xiaowei Zhang, Jian Feng, Xu Wang, Cong-Xiao Cai, Yu Wang, Jian Salvi, Richard Teng, Gao-Jun Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients |
title | Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients |
title_full | Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients |
title_fullStr | Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients |
title_full_unstemmed | Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients |
title_short | Altered Interhemispheric Functional Coordination in Chronic Tinnitus Patients |
title_sort | altered interhemispheric functional coordination in chronic tinnitus patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350869/ https://www.ncbi.nlm.nih.gov/pubmed/25789314 http://dx.doi.org/10.1155/2015/345647 |
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