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Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease
Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350874/ https://www.ncbi.nlm.nih.gov/pubmed/25788942 http://dx.doi.org/10.1155/2015/276575 |
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author | Kalyoncu, Derya Urganci, Nafiye |
author_facet | Kalyoncu, Derya Urganci, Nafiye |
author_sort | Kalyoncu, Derya |
collection | PubMed |
description | Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up. Results. None of the patients had antithyroid antibodies at diagnosis. Antithyroid antibodies became positive in 16.4% of the patients (11/67) 2 to 3 years after the diagnosis of CD. Clinical hypothyroidism was observed only in 3 of 11 CD patients with positive antithyroid antibodies (27.2%). The antithyroid antibodies positive and negative patients did not differ significantly according to compliance to GFD (P > 0.05). A statistically significant difference was observed only in age, in which the patients with positive antithyroid antibodies were younger than the patients with negative antithyroid antibodies (P = 0.004). None of the patients had any change in their thyroid function and antibody profile during their follow-up. Conclusion. Antithyroid antibodies were detected in younger pediatric patients with CD and the prevalence of antithyroid antibodies did not correlate with the duration of gluten intake. |
format | Online Article Text |
id | pubmed-4350874 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43508742015-03-18 Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease Kalyoncu, Derya Urganci, Nafiye Int J Endocrinol Research Article Objective. Aim of the study was to determine the prevalence of autoimmune thyroid disease, persistence of antithyroid antibodies, effect of gluten-free diet, and long-term outcome of thyroid function in pediatric patients with celiac disease (CD). Methods. 67 patients with CD aged from 1 year to 16 years were screened for thyroid antithyroperoxidase, antithyroglobulin and anti-TSH receptor antibodies, serum free triiodothyronine, free thyroxine, and thyroid-stimulating hormone (TSH) at diagnosis and during follow-up. Results. None of the patients had antithyroid antibodies at diagnosis. Antithyroid antibodies became positive in 16.4% of the patients (11/67) 2 to 3 years after the diagnosis of CD. Clinical hypothyroidism was observed only in 3 of 11 CD patients with positive antithyroid antibodies (27.2%). The antithyroid antibodies positive and negative patients did not differ significantly according to compliance to GFD (P > 0.05). A statistically significant difference was observed only in age, in which the patients with positive antithyroid antibodies were younger than the patients with negative antithyroid antibodies (P = 0.004). None of the patients had any change in their thyroid function and antibody profile during their follow-up. Conclusion. Antithyroid antibodies were detected in younger pediatric patients with CD and the prevalence of antithyroid antibodies did not correlate with the duration of gluten intake. Hindawi Publishing Corporation 2015 2015-02-19 /pmc/articles/PMC4350874/ /pubmed/25788942 http://dx.doi.org/10.1155/2015/276575 Text en Copyright © 2015 D. Kalyoncu and N. Urganci. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kalyoncu, Derya Urganci, Nafiye Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
title | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
title_full | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
title_fullStr | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
title_full_unstemmed | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
title_short | Antithyroid Antibodies and Thyroid Function in Pediatric Patients with Celiac Disease |
title_sort | antithyroid antibodies and thyroid function in pediatric patients with celiac disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350874/ https://www.ncbi.nlm.nih.gov/pubmed/25788942 http://dx.doi.org/10.1155/2015/276575 |
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