Overexpression of cystatin C in synovium does not reduce synovitis or cartilage degradation in established osteoarthritis

INTRODUCTION: Cathepsin K (catK) expression is increased in cartilage, bone and synovium during osteoarthritis (OA). To study the role of catK expression and elevated cathepsin activity in the synovium on cartilage destruction in established OA, we overexpressed cystatin C (cysC), a natural cysteine...

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Detalles Bibliográficos
Autores principales: Kyostio-Moore, Sirkka, Piraino, Susan, Berthelette, Patricia, Moran, Nance, Serriello, Joseph, Bendele, Alison, Sookdeo, Cathleen, Nambiar, Bindu, Ewing, Patty, Armentano, Donna, Matthews, Gloria L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350912/
https://www.ncbi.nlm.nih.gov/pubmed/25592743
http://dx.doi.org/10.1186/s13075-015-0519-3

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