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Dexmedetomidine inhibits Tetrodotoxin-resistant Na(v)1.8 sodium channel activity through G(i/o)-dependent pathway in rat dorsal root ganglion neurons

BACKGROUND: Systemically administered dexmedetomidine (DEX), a selective α2 adrenergic receptor (α2-AR) agonists, produces analgesia and sedation. Peripherally restricted α2-AR antagonist could block the analgesic effect of systemic DEX on neuropathic pain, with no effect on sedation, indicating per...

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Detalles Bibliográficos
Autores principales:	Gu, Xi-Yao, Liu, Ben-Long, Zang, Kai-Kai, Yang, Liu, Xu, Hua, Pan, Hai-Li, Zhao, Zhi-Qi, Zhang, Yu-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350947/ https://www.ncbi.nlm.nih.gov/pubmed/25761941 http://dx.doi.org/10.1186/s13041-015-0105-2

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