Constitutively Active Signaling by the G Protein βγ-Subunit Mediates Intrinsically Increased Phosphodiesterase-4 Activity in Human Asthmatic Airway Smooth Muscle Cells

Signaling by the Gβγ subunit of Gi protein, leading to downstream c-Src-induced activation of the Ras/c-Raf1/MEK-ERK1/2 signaling pathway and its upregulation of phosphodiesterase-4 (PDE4) activity, was recently shown to mediate the heightened contractility in proasthmatic sensitized isolated airway...

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Detalles Bibliográficos
Autores principales: Hu, Aihua, Diener, Barry L., Josephson, Maureen B., Grunstein, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351001/
https://www.ncbi.nlm.nih.gov/pubmed/25742624
http://dx.doi.org/10.1371/journal.pone.0118712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351001/
https://www.ncbi.nlm.nih.gov/pubmed/25742624
http://dx.doi.org/10.1371/journal.pone.0118712

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