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Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey

BACKGROUND: Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range (‘low-grade albuminuria’) are associated with cardiovascular morbidity and mortality in the general population. METHODS: We studied 9,736 participants with albuminuria in the...

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Autores principales: Hong, Jae Won, Ku, Cheol Ryong, Noh, Jung Hyun, Ko, Kyung Soo, Rhee, Byoung Doo, Kim, Dong-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351058/
https://www.ncbi.nlm.nih.gov/pubmed/25742159
http://dx.doi.org/10.1371/journal.pone.0118866
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author Hong, Jae Won
Ku, Cheol Ryong
Noh, Jung Hyun
Ko, Kyung Soo
Rhee, Byoung Doo
Kim, Dong-Jun
author_facet Hong, Jae Won
Ku, Cheol Ryong
Noh, Jung Hyun
Ko, Kyung Soo
Rhee, Byoung Doo
Kim, Dong-Jun
author_sort Hong, Jae Won
collection PubMed
description BACKGROUND: Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range (‘low-grade albuminuria’) are associated with cardiovascular morbidity and mortality in the general population. METHODS: We studied 9,736 participants with albuminuria in the normal range from the 2011–2012 Korea National Health and Nutrition Examination Survey (KNHANES). RESULTS: The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89–5.15 and 5.16–7.36 mg/g Cr, respectively. CONCLUSION: Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.
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spelling pubmed-43510582015-03-17 Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey Hong, Jae Won Ku, Cheol Ryong Noh, Jung Hyun Ko, Kyung Soo Rhee, Byoung Doo Kim, Dong-Jun PLoS One Research Article BACKGROUND: Recent studies have indicated that low UACR levels (<30 μg/mg) previously considered to be in the normal range (‘low-grade albuminuria’) are associated with cardiovascular morbidity and mortality in the general population. METHODS: We studied 9,736 participants with albuminuria in the normal range from the 2011–2012 Korea National Health and Nutrition Examination Survey (KNHANES). RESULTS: The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) ≥ 20% (high risk) were 22.5 ± 0.7% and 14.5 ± 0.7%, respectively, in males and 23.3 ± 0.8% and 8.5 ± 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 ± 1.1, 20.2 ± 1.2, 32.4 ± 1.5%, respectively; P < 0.001; and females, 17.6 ± 1.0, 22.7 ± 1.0, 30.2 ± 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 ± 0.7, 12.3 ± 0.9, 22.5 ± 1.2, respectively; P < 0.001; and females, 5.8 ± 0.6, 7.9 ± 0.7, 12.0 ± 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89–5.15 and 5.16–7.36 mg/g Cr, respectively. CONCLUSION: Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans. Public Library of Science 2015-03-05 /pmc/articles/PMC4351058/ /pubmed/25742159 http://dx.doi.org/10.1371/journal.pone.0118866 Text en © 2015 Hong et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hong, Jae Won
Ku, Cheol Ryong
Noh, Jung Hyun
Ko, Kyung Soo
Rhee, Byoung Doo
Kim, Dong-Jun
Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
title Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
title_full Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
title_fullStr Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
title_full_unstemmed Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
title_short Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011–2012 Korea National Health and Nutrition Examination Survey
title_sort association between low-grade albuminuria and cardiovascular risk in korean adults: the 2011–2012 korea national health and nutrition examination survey
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351058/
https://www.ncbi.nlm.nih.gov/pubmed/25742159
http://dx.doi.org/10.1371/journal.pone.0118866
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