Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters

A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal st...

Descripción completa

Detalles Bibliográficos
Autores principales: Chidan Kumar, C. S., Loh, Wan-Sin, Chandraju, Siddegowda, Win, Yip-Foo, Tan, Weng Kang, Quah, Ching Kheng, Fun, Hoong-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351070/
https://www.ncbi.nlm.nih.gov/pubmed/25742494
http://dx.doi.org/10.1371/journal.pone.0119440
_version_ 1782360283732246528
author Chidan Kumar, C. S.
Loh, Wan-Sin
Chandraju, Siddegowda
Win, Yip-Foo
Tan, Weng Kang
Quah, Ching Kheng
Fun, Hoong-Kun
author_facet Chidan Kumar, C. S.
Loh, Wan-Sin
Chandraju, Siddegowda
Win, Yip-Foo
Tan, Weng Kang
Quah, Ching Kheng
Fun, Hoong-Kun
author_sort Chidan Kumar, C. S.
collection PubMed
description A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity.
format Online
Article
Text
id pubmed-4351070
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-43510702015-03-17 Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters Chidan Kumar, C. S. Loh, Wan-Sin Chandraju, Siddegowda Win, Yip-Foo Tan, Weng Kang Quah, Ching Kheng Fun, Hoong-Kun PLoS One Research Article A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity. Public Library of Science 2015-03-05 /pmc/articles/PMC4351070/ /pubmed/25742494 http://dx.doi.org/10.1371/journal.pone.0119440 Text en © 2015 Chidan Kumar et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chidan Kumar, C. S.
Loh, Wan-Sin
Chandraju, Siddegowda
Win, Yip-Foo
Tan, Weng Kang
Quah, Ching Kheng
Fun, Hoong-Kun
Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
title Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
title_full Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
title_fullStr Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
title_full_unstemmed Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
title_short Synthesis, Structural and Antioxidant Studies of Some Novel N-Ethyl Phthalimide Esters
title_sort synthesis, structural and antioxidant studies of some novel n-ethyl phthalimide esters
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351070/
https://www.ncbi.nlm.nih.gov/pubmed/25742494
http://dx.doi.org/10.1371/journal.pone.0119440
work_keys_str_mv AT chidankumarcs synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters
AT lohwansin synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters
AT chandrajusiddegowda synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters
AT winyipfoo synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters
AT tanwengkang synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters
AT quahchingkheng synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters
AT funhoongkun synthesisstructuralandantioxidantstudiesofsomenovelnethylphthalimideesters

Ejemplares similares