Structural basis for bifunctional peptide recognition at human δ-Opioid receptor

Bi-functional μ- and δ- opioid receptor (OR) ligands are potential therapeutic alternatives to alkaloid opiate analgesics with diminished side effects. We solved the structure of human δ-OR bound to the bi-functional δ-OR antagonist and μ-OR agonist tetrapeptide H-Dmt(1)-Tic(2)-Phe(3)-Phe(4)-NH(2) (...

Descripción completa

Detalles Bibliográficos
Autores principales: Fenalti, Gustavo, Zatsepin, Nadia A., Betti, Cecilia, Giguere, Patrick, Han, Gye Won, Ishchenko, Andrii, Liu, Wei, Guillemyn, Karel, Zhang, Haitao, James, Daniel, Wang, Dingjie, Weierstall, Uwe, Spence, John C.H., Boutet, Sébastien, Messerschmidt, Marc, Williams, Garth J., Gati, Cornelius, Yefanov, Oleksandr M., White, Thomas A., Oberthuer, Dominik, Metz, Markus, Yoon, Chun Hong, Barty, Anton, Chapman, Henry N., Basu, Shibom, Coe, Jesse, Conrad, Chelsie E., Fromme, Raimund, Fromme, Petra, Tourwé, Dirk, Schiller, Peter W., Roth, Bryan L., Ballet, Steven, Katritch, Vsevolod, Stevens, Raymond C., Cherezov, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351130/
https://www.ncbi.nlm.nih.gov/pubmed/25686086
http://dx.doi.org/10.1038/nsmb.2965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351130/
https://www.ncbi.nlm.nih.gov/pubmed/25686086
http://dx.doi.org/10.1038/nsmb.2965

Ejemplares similares