Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia

DNMT3B encodes a DNA methyltransferase implicated in aberrant epigenetic changes contributing to leukemogenesis. We tested whether DNMT3B expression, measured by NanoString nCounter assay, associates with outcome, gene- and microRNA-expression and DNA methylation profiles in 210 older (≥60 years) ad...

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Detalles Bibliográficos
Autores principales: Niederwieser, Christian, Kohlschmidt, Jessica, Volinia, Stefano, Whitman, Susan P., Metzeler, Klaus H., Eisfeld, Ann-Kathrin, Maharry, Kati, Yan, Pearlly, Frankhouser, David, Becker, Heiko, Schwind, Sebastian, Carroll, Andrew J., Nicolet, Deedra, Mendler, Jason H., Curfman, John P., Wu, Yue-Zhong, Baer, Maria R., Powell, Bayard L., Kolitz, Jonathan E., Moore, Joseph O., Carter, Thomas H., Bundschuh, Ralf, Larson, Richard A., Stone, Richard M., Mrózek, Krzysztof, Marcucci, Guido, Bloomfield, Clara D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351165/
https://www.ncbi.nlm.nih.gov/pubmed/25204569
http://dx.doi.org/10.1038/leu.2014.267

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