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DNA interstrand cross-link repair requires replication fork convergence
DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and are therefore extremely cytotoxic. In metazoans, a major pathway of ICL repair is coupled to DNA replication and requires the Fanconi anemia pathway. In most current models, collision of a singl...
Autores principales: | Zhang, Jieqiong, Dewar, James M., Budzowska, Magda, Motnenko, Anna, Cohn, Martin A., Walter, Johannes C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351167/ https://www.ncbi.nlm.nih.gov/pubmed/25643322 http://dx.doi.org/10.1038/nsmb.2956 |
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