Mechanism of Microhomology-Mediated End-Joining Promoted by Human DNA Polymerase Theta

Microhomology-mediated end-joining (MMEJ) is an error-prone alternative double-strand break repair pathway that utilizes sequence microhomology to recombine broken DNA. Although MMEJ is implicated in cancer development, the mechanism of this pathway is unknown. We demonstrate that purified human DNA...

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Detalles Bibliográficos
Autores principales: Kent, Tatiana, Chandramouly, Gurushankar, McDevitt, Shane Michael, Ozdemir, Ahmet Y., Pomerantz, Richard T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351179/
https://www.ncbi.nlm.nih.gov/pubmed/25643323
http://dx.doi.org/10.1038/nsmb.2961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351179/
https://www.ncbi.nlm.nih.gov/pubmed/25643323
http://dx.doi.org/10.1038/nsmb.2961

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