Aberrant Splicing in Transgenes Containing Introns, Exons, and V5 Epitopes: Lessons from Developing an FSHD Mouse Model Expressing a D4Z4 Repeat with Flanking Genomic Sequences

The DUX4 gene, encoded within D4Z4 repeats on human chromosome 4q35, has recently emerged as a key factor in the pathogenic mechanisms underlying Facioscapulohumeral muscular dystrophy (FSHD). This recognition prompted development of animal models expressing the DUX4 open reading frame (ORF) alone o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ansseau, Eugénie, Domire, Jacqueline S., Wallace, Lindsay M., Eidahl, Jocelyn O., Guckes, Susan M., Giesige, Carlee R., Pyne, Nettie K., Belayew, Alexandra, Harper, Scott Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351184/
https://www.ncbi.nlm.nih.gov/pubmed/25742305
http://dx.doi.org/10.1371/journal.pone.0118813

Ejemplares similares

Ejemplares similares