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A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy()

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers principally because of early invasion and metastasis. The epidermal growth factor receptor (EGFR) is essential for PDAC development even in the presence of Kras, but its inhibition with erlotinib gives only a modest clinical r...

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Detalles Bibliográficos
Autores principales:	Cardone, Rosa Angela, Greco, Maria Raffaella, Zeeberg, Katrine, Zaccagnino, Angela, Saccomano, Mara, Bellizzi, Antonia, Bruns, Philipp, Menga, Marta, Pilarsky, Christian, Schwab, Albrecht, Alves, Frauke, Kalthoff, Holger, Casavola, Valeria, Reshkin, Stephan Joel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351296/ https://www.ncbi.nlm.nih.gov/pubmed/25748234 http://dx.doi.org/10.1016/j.neo.2014.12.003

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