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Constitutively Active Akt1 Cooperates with KRas(G12D) to Accelerate In Vivo Pancreatic Tumor Onset and Progression()()

BACKGROUND AND AIMS: Pancreatic adenocarcinoma is a deadly disease characterized by metastatic progression and resistance to conventional therapeutics. Mutation of KRAS is the most frequent early event in pancreatic tumor progression. AKT isoforms are frequently activated in pancreatic cancer, and r...

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Detalles Bibliográficos
Autores principales:	Albury, Toya M., Pandey, Veethika, Gitto, Sarah B., Dominguez, Lisette, Spinel, Lina P., Talarchek, Jacqueline, Klein-Szanto, Andres J., Testa, Joseph R., Altomare, Deborah A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351297/ https://www.ncbi.nlm.nih.gov/pubmed/25748236 http://dx.doi.org/10.1016/j.neo.2014.12.006

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