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Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
BACKGROUND/AIMS: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Association of Internal Medicine
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351326/ https://www.ncbi.nlm.nih.gov/pubmed/25750561 http://dx.doi.org/10.3904/kjim.2015.30.2.198 |
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author | Lee, Wan Soo Kang, Dae Woong Back, Jong Hun Kim, Hyun Lee Chung, Jong Hoon Shin, Byung Chul |
author_facet | Lee, Wan Soo Kang, Dae Woong Back, Jong Hun Kim, Hyun Lee Chung, Jong Hoon Shin, Byung Chul |
author_sort | Lee, Wan Soo |
collection | PubMed |
description | BACKGROUND/AIMS: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought to determine an appropriate threshold level. METHODS: Serum PCT levels were measured in ESRD patients on antibiotic therapy for a suspected bacterial infection (ESRD infection [iESRD] group, n = 21), and compared with those of ESRD patients on hemodialysis with no sign of infection (ESRD control [cESRD] group, n = 20). RESULTS: The mean serum PCT concentration of the iESRD group was significantly higher than in the cESRD group (2.95 ± 3.67 ng/mL vs. 0.50 ± 0.49 ng/mL, p = 0.006), but serum PCT concentrations did not correlate with severity of infection. The optimized threshold level derived for serum PCT was 0.75 ng/mL, rather than the currently used 0.5 ng/mL; this threshold demonstrated a sensitivity and specificity of 76.2% and 80.0% for infection and 100% and 60.6% for systemic inflammatory response syndrome, respectively, compared with the cutoff of 0.5 ng/mL. CONCLUSIONS: This study suggests that serum PCT at a cutoff value of 0.75 ng/mL is an appropriate indicator of infection in ESRD patients. |
format | Online Article Text |
id | pubmed-4351326 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Association of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-43513262015-03-06 Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients Lee, Wan Soo Kang, Dae Woong Back, Jong Hun Kim, Hyun Lee Chung, Jong Hoon Shin, Byung Chul Korean J Intern Med Original Article BACKGROUND/AIMS: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought to determine an appropriate threshold level. METHODS: Serum PCT levels were measured in ESRD patients on antibiotic therapy for a suspected bacterial infection (ESRD infection [iESRD] group, n = 21), and compared with those of ESRD patients on hemodialysis with no sign of infection (ESRD control [cESRD] group, n = 20). RESULTS: The mean serum PCT concentration of the iESRD group was significantly higher than in the cESRD group (2.95 ± 3.67 ng/mL vs. 0.50 ± 0.49 ng/mL, p = 0.006), but serum PCT concentrations did not correlate with severity of infection. The optimized threshold level derived for serum PCT was 0.75 ng/mL, rather than the currently used 0.5 ng/mL; this threshold demonstrated a sensitivity and specificity of 76.2% and 80.0% for infection and 100% and 60.6% for systemic inflammatory response syndrome, respectively, compared with the cutoff of 0.5 ng/mL. CONCLUSIONS: This study suggests that serum PCT at a cutoff value of 0.75 ng/mL is an appropriate indicator of infection in ESRD patients. The Korean Association of Internal Medicine 2015-03 2015-02-27 /pmc/articles/PMC4351326/ /pubmed/25750561 http://dx.doi.org/10.3904/kjim.2015.30.2.198 Text en Copyright © 2015 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Wan Soo Kang, Dae Woong Back, Jong Hun Kim, Hyun Lee Chung, Jong Hoon Shin, Byung Chul Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
title | Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
title_full | Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
title_fullStr | Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
title_full_unstemmed | Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
title_short | Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
title_sort | cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351326/ https://www.ncbi.nlm.nih.gov/pubmed/25750561 http://dx.doi.org/10.3904/kjim.2015.30.2.198 |
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