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Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients

BACKGROUND/AIMS: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought...

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Autores principales: Lee, Wan Soo, Kang, Dae Woong, Back, Jong Hun, Kim, Hyun Lee, Chung, Jong Hoon, Shin, Byung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351326/
https://www.ncbi.nlm.nih.gov/pubmed/25750561
http://dx.doi.org/10.3904/kjim.2015.30.2.198
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author Lee, Wan Soo
Kang, Dae Woong
Back, Jong Hun
Kim, Hyun Lee
Chung, Jong Hoon
Shin, Byung Chul
author_facet Lee, Wan Soo
Kang, Dae Woong
Back, Jong Hun
Kim, Hyun Lee
Chung, Jong Hoon
Shin, Byung Chul
author_sort Lee, Wan Soo
collection PubMed
description BACKGROUND/AIMS: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought to determine an appropriate threshold level. METHODS: Serum PCT levels were measured in ESRD patients on antibiotic therapy for a suspected bacterial infection (ESRD infection [iESRD] group, n = 21), and compared with those of ESRD patients on hemodialysis with no sign of infection (ESRD control [cESRD] group, n = 20). RESULTS: The mean serum PCT concentration of the iESRD group was significantly higher than in the cESRD group (2.95 ± 3.67 ng/mL vs. 0.50 ± 0.49 ng/mL, p = 0.006), but serum PCT concentrations did not correlate with severity of infection. The optimized threshold level derived for serum PCT was 0.75 ng/mL, rather than the currently used 0.5 ng/mL; this threshold demonstrated a sensitivity and specificity of 76.2% and 80.0% for infection and 100% and 60.6% for systemic inflammatory response syndrome, respectively, compared with the cutoff of 0.5 ng/mL. CONCLUSIONS: This study suggests that serum PCT at a cutoff value of 0.75 ng/mL is an appropriate indicator of infection in ESRD patients.
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spelling pubmed-43513262015-03-06 Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients Lee, Wan Soo Kang, Dae Woong Back, Jong Hun Kim, Hyun Lee Chung, Jong Hoon Shin, Byung Chul Korean J Intern Med Original Article BACKGROUND/AIMS: Serum procalcitonin (PCT) levels are low in healthy individuals but are elevated in patients with a serious bacterial infection or sepsis. In this study, we examined the ability of serum PCT concentration to diagnose infections in end-stage renal disease (ESRD) patients, and sought to determine an appropriate threshold level. METHODS: Serum PCT levels were measured in ESRD patients on antibiotic therapy for a suspected bacterial infection (ESRD infection [iESRD] group, n = 21), and compared with those of ESRD patients on hemodialysis with no sign of infection (ESRD control [cESRD] group, n = 20). RESULTS: The mean serum PCT concentration of the iESRD group was significantly higher than in the cESRD group (2.95 ± 3.67 ng/mL vs. 0.50 ± 0.49 ng/mL, p = 0.006), but serum PCT concentrations did not correlate with severity of infection. The optimized threshold level derived for serum PCT was 0.75 ng/mL, rather than the currently used 0.5 ng/mL; this threshold demonstrated a sensitivity and specificity of 76.2% and 80.0% for infection and 100% and 60.6% for systemic inflammatory response syndrome, respectively, compared with the cutoff of 0.5 ng/mL. CONCLUSIONS: This study suggests that serum PCT at a cutoff value of 0.75 ng/mL is an appropriate indicator of infection in ESRD patients. The Korean Association of Internal Medicine 2015-03 2015-02-27 /pmc/articles/PMC4351326/ /pubmed/25750561 http://dx.doi.org/10.3904/kjim.2015.30.2.198 Text en Copyright © 2015 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Wan Soo
Kang, Dae Woong
Back, Jong Hun
Kim, Hyun Lee
Chung, Jong Hoon
Shin, Byung Chul
Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
title Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
title_full Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
title_fullStr Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
title_full_unstemmed Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
title_short Cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
title_sort cutoff value of serum procalcitonin as a diagnostic biomarker of infection in end-stage renal disease patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351326/
https://www.ncbi.nlm.nih.gov/pubmed/25750561
http://dx.doi.org/10.3904/kjim.2015.30.2.198
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