Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the UPS, in which Ub-conjugated substrates are deubiquitinated,...

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Detalles Bibliográficos
Autores principales: Ciechanover, Aaron, Kwon, Yong Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351408/
https://www.ncbi.nlm.nih.gov/pubmed/25766616
http://dx.doi.org/10.1038/emm.2014.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351408/
https://www.ncbi.nlm.nih.gov/pubmed/25766616
http://dx.doi.org/10.1038/emm.2014.117

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