IL-21 production by CD4(+) effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

AIMS/HYPOTHESIS: Type 1 diabetes results from the autoimmune destruction of insulin-secreting pancreatic beta cells by T cells. Despite the established role of T cells in the pathogenesis of the disease, to date, with the exception of the identification of islet-specific T effector (Teff) cells, stu...

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Detalles Bibliográficos
Autores principales: Ferreira, Ricardo C., Simons, Henry Z., Thompson, Whitney S., Cutler, Antony J., Dopico, Xaquin Castro, Smyth, Deborah J., Mashar, Meghavi, Schuilenburg, Helen, Walker, Neil M., Dunger, David B., Wallace, Chris, Todd, John A., Wicker, Linda S., Pekalski, Marcin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351433/
https://www.ncbi.nlm.nih.gov/pubmed/25652388
http://dx.doi.org/10.1007/s00125-015-3509-8

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