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Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling
Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arte...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351572/ https://www.ncbi.nlm.nih.gov/pubmed/25716000 http://dx.doi.org/10.1038/ncomms7241 |
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author | Sumida, Tomokazu Naito, Atsuhiko T. Nomura, Seitaro Nakagawa, Akito Higo, Tomoaki Hashimoto, Akihito Okada, Katsuki Sakai, Taku Ito, Masamichi Yamaguchi, Toshihiro Oka, Toru Akazawa, Hiroshi Lee, Jong-Kook Minamino, Tohru Offermanns, Stefan Noda, Tetsuo Botto, Marina Kobayashi, Yoshio Morita, Hiroyuki Manabe, Ichiro Nagai, Toshio Shiojima, Ichiro Komuro, Issei |
author_facet | Sumida, Tomokazu Naito, Atsuhiko T. Nomura, Seitaro Nakagawa, Akito Higo, Tomoaki Hashimoto, Akihito Okada, Katsuki Sakai, Taku Ito, Masamichi Yamaguchi, Toshihiro Oka, Toru Akazawa, Hiroshi Lee, Jong-Kook Minamino, Tohru Offermanns, Stefan Noda, Tetsuo Botto, Marina Kobayashi, Yoshio Morita, Hiroyuki Manabe, Ichiro Nagai, Toshio Shiojima, Ichiro Komuro, Issei |
author_sort | Sumida, Tomokazu |
collection | PubMed |
description | Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling remain elusive. We have recently reported that complement C1q activates β-catenin signalling independent of Wnts. Here, we show a critical role of complement C1-induced activation of β-catenin signalling in hypertensive arterial remodelling. Activation of β-catenin and proliferation of VSMCs were observed after blood-pressure elevation, which were prevented by genetic and chemical inhibition of β-catenin signalling. Macrophage depletion and C1qa gene deletion attenuated the hypertension-induced β-catenin signalling, proliferation of VSMCs and pathological arterial remodelling. Our findings unveil the link between complement C1 and arterial remodelling and suggest that C1-induced activation of β-catenin signalling becomes a novel therapeutic target to prevent arteriosclerosis in patients with hypertension. |
format | Online Article Text |
id | pubmed-4351572 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43515722015-03-19 Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling Sumida, Tomokazu Naito, Atsuhiko T. Nomura, Seitaro Nakagawa, Akito Higo, Tomoaki Hashimoto, Akihito Okada, Katsuki Sakai, Taku Ito, Masamichi Yamaguchi, Toshihiro Oka, Toru Akazawa, Hiroshi Lee, Jong-Kook Minamino, Tohru Offermanns, Stefan Noda, Tetsuo Botto, Marina Kobayashi, Yoshio Morita, Hiroyuki Manabe, Ichiro Nagai, Toshio Shiojima, Ichiro Komuro, Issei Nat Commun Article Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling remain elusive. We have recently reported that complement C1q activates β-catenin signalling independent of Wnts. Here, we show a critical role of complement C1-induced activation of β-catenin signalling in hypertensive arterial remodelling. Activation of β-catenin and proliferation of VSMCs were observed after blood-pressure elevation, which were prevented by genetic and chemical inhibition of β-catenin signalling. Macrophage depletion and C1qa gene deletion attenuated the hypertension-induced β-catenin signalling, proliferation of VSMCs and pathological arterial remodelling. Our findings unveil the link between complement C1 and arterial remodelling and suggest that C1-induced activation of β-catenin signalling becomes a novel therapeutic target to prevent arteriosclerosis in patients with hypertension. Nature Pub. Group 2015-02-26 /pmc/articles/PMC4351572/ /pubmed/25716000 http://dx.doi.org/10.1038/ncomms7241 Text en Copyright © 2015, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Sumida, Tomokazu Naito, Atsuhiko T. Nomura, Seitaro Nakagawa, Akito Higo, Tomoaki Hashimoto, Akihito Okada, Katsuki Sakai, Taku Ito, Masamichi Yamaguchi, Toshihiro Oka, Toru Akazawa, Hiroshi Lee, Jong-Kook Minamino, Tohru Offermanns, Stefan Noda, Tetsuo Botto, Marina Kobayashi, Yoshio Morita, Hiroyuki Manabe, Ichiro Nagai, Toshio Shiojima, Ichiro Komuro, Issei Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
title | Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
title_full | Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
title_fullStr | Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
title_full_unstemmed | Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
title_short | Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
title_sort | complement c1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351572/ https://www.ncbi.nlm.nih.gov/pubmed/25716000 http://dx.doi.org/10.1038/ncomms7241 |
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