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High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons
This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100 kHz) duty cycled signal. By means of tissue modeling that includes the dynamic p...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351622/ https://www.ncbi.nlm.nih.gov/pubmed/25798105 http://dx.doi.org/10.3389/fneng.2015.00002 |
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author | van Dongen, Marijn N. Hoebeek, Freek E. Koekkoek, S. K. E. De Zeeuw, Chris I. Serdijn, Wouter A. |
author_facet | van Dongen, Marijn N. Hoebeek, Freek E. Koekkoek, S. K. E. De Zeeuw, Chris I. Serdijn, Wouter A. |
author_sort | van Dongen, Marijn N. |
collection | PubMed |
description | This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100 kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well as the axon membrane, it is first shown that switched-mode stimulation depolarizes the cell membrane in a similar way as classical constant amplitude stimulation. These findings are subsequently verified using in vitro experiments in which the response of a Purkinje cell is measured due to a stimulation signal in the molecular layer of the cerebellum of a mouse. For this purpose a stimulator circuit is developed that is able to produce a monophasic high frequency switched-mode stimulation signal. The results confirm the modeling by showing that switched-mode stimulation is able to induce similar responses in the Purkinje cell as classical stimulation using a constant current source. This conclusion opens up possibilities for novel stimulation designs that can improve the performance of the stimulator circuitry. Care has to be taken to avoid losses in the system due to the higher operating frequency. |
format | Online Article Text |
id | pubmed-4351622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43516222015-03-20 High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons van Dongen, Marijn N. Hoebeek, Freek E. Koekkoek, S. K. E. De Zeeuw, Chris I. Serdijn, Wouter A. Front Neuroeng Neuroscience This paper investigates the efficacy of high frequency switched-mode neural stimulation. Instead of using a constant stimulation amplitude, the stimulus is switched on and off repeatedly with a high frequency (up to 100 kHz) duty cycled signal. By means of tissue modeling that includes the dynamic properties of both the tissue material as well as the axon membrane, it is first shown that switched-mode stimulation depolarizes the cell membrane in a similar way as classical constant amplitude stimulation. These findings are subsequently verified using in vitro experiments in which the response of a Purkinje cell is measured due to a stimulation signal in the molecular layer of the cerebellum of a mouse. For this purpose a stimulator circuit is developed that is able to produce a monophasic high frequency switched-mode stimulation signal. The results confirm the modeling by showing that switched-mode stimulation is able to induce similar responses in the Purkinje cell as classical stimulation using a constant current source. This conclusion opens up possibilities for novel stimulation designs that can improve the performance of the stimulator circuitry. Care has to be taken to avoid losses in the system due to the higher operating frequency. Frontiers Media S.A. 2015-03-06 /pmc/articles/PMC4351622/ /pubmed/25798105 http://dx.doi.org/10.3389/fneng.2015.00002 Text en Copyright © 2015 van Dongen, Hoebeek, Koekkoek, De Zeeuw and Serdijn. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience van Dongen, Marijn N. Hoebeek, Freek E. Koekkoek, S. K. E. De Zeeuw, Chris I. Serdijn, Wouter A. High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
title | High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
title_full | High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
title_fullStr | High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
title_full_unstemmed | High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
title_short | High frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
title_sort | high frequency switched-mode stimulation can evoke post synaptic responses in cerebellar principal neurons |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351622/ https://www.ncbi.nlm.nih.gov/pubmed/25798105 http://dx.doi.org/10.3389/fneng.2015.00002 |
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