Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial

BACKGROUND: Osteoarthritis (OA) is the fastest growing cause of disability worldwide. Current treatments for OA are severely limited and a large proportion of people with OA live in constant, debilitating pain. There is therefore an urgent need for novel treatments to reduce pain. Synovitis is highl...

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Detalles Bibliográficos
Autores principales: Kingsbury, Sarah R, Tharmanathan, Puvan, Arden, Nigel K, Batley, Michael, Birrell, Fraser, Cocks, Kim, Doherty, Michael, Edwards, Chris J, Garrood, Toby, Grainger, Andrew J, Green, Michael, Hewitt, Catherine, Hughes, Rod, Moots, Robert, O’Neill, Terence W, Roddy, Edward, Scott, David L, Watt, Fiona E, Torgerson, David J, Conaghan, Philip G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351849/
https://www.ncbi.nlm.nih.gov/pubmed/25872649
http://dx.doi.org/10.1186/s13063-015-0602-8

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