Zileuton, 5-Lipoxygenase Inhibitor, Acts as a Chemopreventive Agent in Intestinal Polyposis, by Modulating Polyp and Systemic Inflammation

PURPOSE: Leukotrienes and prostaglandins, products of arachidonic acid metabolism, sustain both systemic and lesion-localized inflammation. Tumor-associated Inflammation can also contribute to the pathogenesis of colon cancer. Patients with inflammatory bowel disease (IBD) have increased risk of dev...

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Detalles Bibliográficos
Autores principales: Gounaris, Elias, Heiferman, Michael J., Heiferman, Jeffrey R., Shrivastav, Manisha, Vitello, Dominic, Blatner, Nichole R., Knab, Lawrence M., Phillips, Joseph D., Cheon, Eric C., Grippo, Paul J., Khazaie, Khashayarsha, Munshi, Hidayatullah G., Bentrem, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351892/
https://www.ncbi.nlm.nih.gov/pubmed/25747113
http://dx.doi.org/10.1371/journal.pone.0121402

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