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miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia

BACKGROUND: Core Binding Factor acute myeloid leukemia (CBF-AML) with t(8;21) RUNX1-MTG8 or inv(16) CBFB-MYH11 fusion proteins often show upregulation of wild type or mutated KIT receptor. However, also non-CBF-AML frequently displays upregulated KIT expression. In the first part of this study we sh...

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Detalles Bibliográficos
Autores principales:	Fischer, John Adams, Rossetti, Stefano, Datta, Arani, Eng, Kevin Hasegawa, Beghini, Alessandro, Sacchi, Nicoletta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4351976/ https://www.ncbi.nlm.nih.gov/pubmed/25612891 http://dx.doi.org/10.1186/s12943-014-0283-z

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