Bioactivity-Guided Fractionation of an Antidiarrheal Chinese Herb Rhodiola kirilowii (Regel) Maxim Reveals (-)–Epicatechin-3-Gallate and (-)–Epigallocatechin-3-Gallate as Inhibitors of Cystic Fibrosis Transmembrane Conductance Regulator

Cystic fibrosis transmembrane conductance regulator (CFTR) is the principal apical route for transepithelial fluid transport induced by enterotoxin. Inhibition of CFTR has been confirmed as a pharmaceutical approach for the treatment of secretory diarrhea. Many traditional Chinese herbal medicines,...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Yu, Bo, Zhang, Yaofang, Gao, Xin, Zhu, Liang, Ma, Tonghui, Yang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352019/
https://www.ncbi.nlm.nih.gov/pubmed/25747701
http://dx.doi.org/10.1371/journal.pone.0119122

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