Preclinical Studies Identify Non-Apoptotic Low-Level Caspase-3 as Therapeutic Target in Pemphigus Vulgaris

The majority of pemphigus vulgaris (PV) patients suffer from a live-threatening loss of intercellular adhesion between keratinocytes (acantholysis). The disease is caused by auto-antibodies that bind to desmosomal cadherins desmoglein (Dsg) 3 or Dsg3 and Dsg1 in mucous membranes and skin. A currentl...

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Detalles Bibliográficos
Autores principales: Luyet, Camille, Schulze, Katja, Sayar, Beyza S., Howald, Denise, Müller, Eliane J., Galichet, Arnaud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352034/
https://www.ncbi.nlm.nih.gov/pubmed/25748204
http://dx.doi.org/10.1371/journal.pone.0119809

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