A High-Throughput In Vitro Drug Screen in a Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma Identifies BMS-754807 as a Promising Therapeutic Agent

Diffuse intrinsic pontine gliomas (DIPGs) represent a particularly lethal type of pediatric brain cancer with no effective therapeutic options. Our laboratory has previously reported the development of genetically engineered DIPG mouse models using the RCAS/tv-a system, including a model driven by P...

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Detalles Bibliográficos
Autores principales: Halvorson, Kyle G., Barton, Kelly L., Schroeder, Kristin, Misuraca, Katherine L., Hoeman, Christine, Chung, Alex, Crabtree, Donna M., Cordero, Francisco J., Singh, Raj, Spasojevic, Ivan, Berlow, Noah, Pal, Ranadip, Becher, Oren J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352073/
https://www.ncbi.nlm.nih.gov/pubmed/25748921
http://dx.doi.org/10.1371/journal.pone.0118926

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