TOPping off meiosis

Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal the role of three of these protein...

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Detalles Bibliográficos
Autor principal: Haber, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352088/
https://www.ncbi.nlm.nih.gov/pubmed/25699706
http://dx.doi.org/10.1016/j.molcel.2015.02.004
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author Haber, James E.
author_facet Haber, James E.
author_sort Haber, James E.
collection PubMed
description Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal the role of three of these proteins in budding yeast: Sgs1 (BLM homolog), Top3 (TOPIIIα homolog) and Rmi1. They demonstrate several steps where all three proteins act together, and find additional functions of the Top3-Rmi1 subcomplex that are critical for the completion of meiosis.
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spelling pubmed-43520882016-02-19 TOPping off meiosis Haber, James E. Mol Cell Article Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal the role of three of these proteins in budding yeast: Sgs1 (BLM homolog), Top3 (TOPIIIα homolog) and Rmi1. They demonstrate several steps where all three proteins act together, and find additional functions of the Top3-Rmi1 subcomplex that are critical for the completion of meiosis. 2015-02-19 /pmc/articles/PMC4352088/ /pubmed/25699706 http://dx.doi.org/10.1016/j.molcel.2015.02.004 Text en © 2015 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc/4.0/ This manuscript version is made available under the CC BY-NC-ND 4.0 license.
spellingShingle Article
Haber, James E.
TOPping off meiosis
title TOPping off meiosis
title_full TOPping off meiosis
title_fullStr TOPping off meiosis
title_full_unstemmed TOPping off meiosis
title_short TOPping off meiosis
title_sort topping off meiosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352088/
https://www.ncbi.nlm.nih.gov/pubmed/25699706
http://dx.doi.org/10.1016/j.molcel.2015.02.004
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