Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity

Interventions that delay ageing mobilize mechanisms that protect and repair cellular components(1–3), but it is unknown how these interventions might slow the functional decline of extracellular matrices(4,5), which are also damaged during ageing(6,7). Reduced Insulin/IGF-1 signalling (rIIS) extends...

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Detalles Bibliográficos
Autores principales: Ewald, Collin Y., Landis, Jess N., Abate, Jess Porter, Murphy, Coleen T., Blackwell, T. Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/
https://www.ncbi.nlm.nih.gov/pubmed/25517099
http://dx.doi.org/10.1038/nature14021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352135/
https://www.ncbi.nlm.nih.gov/pubmed/25517099
http://dx.doi.org/10.1038/nature14021

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