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The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis

BACKGROUND: Pneumococcal meningitis (PM) is characterized by high mortality and morbidity including long-term neurofunctional deficits. Neuropathological correlates of these sequelae are apoptosis in the hippocampal dentate gyrus and necrosis in the cortex. Matrix metalloproteinases (MMPs) play a cr...

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Detalles Bibliográficos
Autores principales:	Liechti, Fabian D, Bächtold, Fabian, Grandgirard, Denis, Leppert, David, Leib, Stephen L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352253/ https://www.ncbi.nlm.nih.gov/pubmed/25890041 http://dx.doi.org/10.1186/s12974-015-0257-0

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