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Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions

Construction of the urinary bladder de novo using tissue engineering technologies is the “holy grail” of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be b...

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Detalles Bibliográficos
Autores principales: Pokrywczynska, Marta, Gubanska, Iga, Drewa, Gerard, Drewa, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352424/
https://www.ncbi.nlm.nih.gov/pubmed/25793199
http://dx.doi.org/10.1155/2015/613439
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author Pokrywczynska, Marta
Gubanska, Iga
Drewa, Gerard
Drewa, Tomasz
author_facet Pokrywczynska, Marta
Gubanska, Iga
Drewa, Gerard
Drewa, Tomasz
author_sort Pokrywczynska, Marta
collection PubMed
description Construction of the urinary bladder de novo using tissue engineering technologies is the “holy grail” of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be bladder acellular matrix (BAM). In this review we determine the most important factors, which may affect biological and physical properties of BAM and its regeneration potential in tissue engineered urinary bladder. We also point out the directions in modification of BAM, which include incorporation of exogenous growth factors into the BAM structure. Finally, we discuss the results of the urinary bladder regeneration with cell seeded BAM.
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spelling pubmed-43524242015-03-19 Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions Pokrywczynska, Marta Gubanska, Iga Drewa, Gerard Drewa, Tomasz Biomed Res Int Review Article Construction of the urinary bladder de novo using tissue engineering technologies is the “holy grail” of reconstructive urology. The search for the ideal biomaterial for urinary bladder reconstruction has been ongoing for decades. One of the most promising biomaterials for this purpose seems to be bladder acellular matrix (BAM). In this review we determine the most important factors, which may affect biological and physical properties of BAM and its regeneration potential in tissue engineered urinary bladder. We also point out the directions in modification of BAM, which include incorporation of exogenous growth factors into the BAM structure. Finally, we discuss the results of the urinary bladder regeneration with cell seeded BAM. Hindawi Publishing Corporation 2015 2015-02-22 /pmc/articles/PMC4352424/ /pubmed/25793199 http://dx.doi.org/10.1155/2015/613439 Text en Copyright © 2015 Marta Pokrywczynska et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pokrywczynska, Marta
Gubanska, Iga
Drewa, Gerard
Drewa, Tomasz
Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions
title Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions
title_full Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions
title_fullStr Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions
title_full_unstemmed Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions
title_short Application of Bladder Acellular Matrix in Urinary Bladder Regeneration: The State of the Art and Future Directions
title_sort application of bladder acellular matrix in urinary bladder regeneration: the state of the art and future directions
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352424/
https://www.ncbi.nlm.nih.gov/pubmed/25793199
http://dx.doi.org/10.1155/2015/613439
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