CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?

CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal...

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Detalles Bibliográficos
Autores principales: Radulovic, Katarina, Niess, Jan Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352431/
https://www.ncbi.nlm.nih.gov/pubmed/25759842
http://dx.doi.org/10.1155/2015/497056
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author Radulovic, Katarina
Niess, Jan Hendrik
author_facet Radulovic, Katarina
Niess, Jan Hendrik
author_sort Radulovic, Katarina
collection PubMed
description CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal microflora (one of the nature's most complex and most densely populated microbial habitats) and food antigens, while only a small number of circulating leukocytes express this molecule. In this review we will discuss the role of CD69 in mucosal tissue and consider CD69 as a potential target for the development of novel treatments of intestinal inflammation.
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spelling pubmed-43524312015-03-10 CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment? Radulovic, Katarina Niess, Jan Hendrik J Immunol Res Review Article CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal microflora (one of the nature's most complex and most densely populated microbial habitats) and food antigens, while only a small number of circulating leukocytes express this molecule. In this review we will discuss the role of CD69 in mucosal tissue and consider CD69 as a potential target for the development of novel treatments of intestinal inflammation. Hindawi Publishing Corporation 2015 2015-02-22 /pmc/articles/PMC4352431/ /pubmed/25759842 http://dx.doi.org/10.1155/2015/497056 Text en Copyright © 2015 K. Radulovic and J. H. Niess. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Radulovic, Katarina
Niess, Jan Hendrik
CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?
title CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?
title_full CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?
title_fullStr CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?
title_full_unstemmed CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?
title_short CD69 Is the Crucial Regulator of Intestinal Inflammation: A New Target Molecule for IBD Treatment?
title_sort cd69 is the crucial regulator of intestinal inflammation: a new target molecule for ibd treatment?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352431/
https://www.ncbi.nlm.nih.gov/pubmed/25759842
http://dx.doi.org/10.1155/2015/497056
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