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The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study

The androgen receptor (AR) and its signaling pathway play an important role in the development and progression of prostate cancer (PCa). In the setting of primary treatment of PCa with radiotherapy (RT), where the AR can be expected to be of more importance, studies evaluating the AR expression are...

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Autores principales: Poelaert, Filip, Van Praet, Charles, Beerens, Anne-Sophie, De Meerleer, Gert, Fonteyne, Valérie, Ost, Piet, Lumen, Nicolaas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352440/
https://www.ncbi.nlm.nih.gov/pubmed/25793207
http://dx.doi.org/10.1155/2015/812815
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author Poelaert, Filip
Van Praet, Charles
Beerens, Anne-Sophie
De Meerleer, Gert
Fonteyne, Valérie
Ost, Piet
Lumen, Nicolaas
author_facet Poelaert, Filip
Van Praet, Charles
Beerens, Anne-Sophie
De Meerleer, Gert
Fonteyne, Valérie
Ost, Piet
Lumen, Nicolaas
author_sort Poelaert, Filip
collection PubMed
description The androgen receptor (AR) and its signaling pathway play an important role in the development and progression of prostate cancer (PCa). In the setting of primary treatment of PCa with radiotherapy (RT), where the AR can be expected to be of more importance, studies evaluating the AR expression are lacking. The goal of this research is to evaluate AR protein expression in hormone-naive PCa patients treated by RT and investigate its possible prognostic role. Primary biopsy samples of 18 patients treated with primary RT were analyzed including the corresponding clinical information. AR protein expression of the tumor epithelium (with highest Gleason pattern) and the surrounding stroma was quantified using the Quick score for steroid receptors. The differential expression between epithelium and stroma, respectively, between tumor and normal tissue (ΔTumor − ΔBenign >2 versus ≤2), was predictive for clinical progression-free survival in the biopsy samples (P = 0.014). Preliminary results of this research show already a promising role of differential AR expression in predicting clinical relapse after PCa treatment with primary EBRT. Further research is needed to validate these findings. Hopefully this can lead to a better understanding of PCa evolution and eventually lead to better therapy strategies.
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spelling pubmed-43524402015-03-19 The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study Poelaert, Filip Van Praet, Charles Beerens, Anne-Sophie De Meerleer, Gert Fonteyne, Valérie Ost, Piet Lumen, Nicolaas Biomed Res Int Research Article The androgen receptor (AR) and its signaling pathway play an important role in the development and progression of prostate cancer (PCa). In the setting of primary treatment of PCa with radiotherapy (RT), where the AR can be expected to be of more importance, studies evaluating the AR expression are lacking. The goal of this research is to evaluate AR protein expression in hormone-naive PCa patients treated by RT and investigate its possible prognostic role. Primary biopsy samples of 18 patients treated with primary RT were analyzed including the corresponding clinical information. AR protein expression of the tumor epithelium (with highest Gleason pattern) and the surrounding stroma was quantified using the Quick score for steroid receptors. The differential expression between epithelium and stroma, respectively, between tumor and normal tissue (ΔTumor − ΔBenign >2 versus ≤2), was predictive for clinical progression-free survival in the biopsy samples (P = 0.014). Preliminary results of this research show already a promising role of differential AR expression in predicting clinical relapse after PCa treatment with primary EBRT. Further research is needed to validate these findings. Hopefully this can lead to a better understanding of PCa evolution and eventually lead to better therapy strategies. Hindawi Publishing Corporation 2015 2015-02-22 /pmc/articles/PMC4352440/ /pubmed/25793207 http://dx.doi.org/10.1155/2015/812815 Text en Copyright © 2015 Filip Poelaert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Poelaert, Filip
Van Praet, Charles
Beerens, Anne-Sophie
De Meerleer, Gert
Fonteyne, Valérie
Ost, Piet
Lumen, Nicolaas
The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study
title The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study
title_full The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study
title_fullStr The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study
title_full_unstemmed The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study
title_short The Role of Androgen Receptor Expression in the Curative Treatment of Prostate Cancer with Radiotherapy: A Pilot Study
title_sort role of androgen receptor expression in the curative treatment of prostate cancer with radiotherapy: a pilot study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352440/
https://www.ncbi.nlm.nih.gov/pubmed/25793207
http://dx.doi.org/10.1155/2015/812815
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