Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery

Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX)...

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Detalles Bibliográficos
Autores principales: Nivsarkar, Megha S., Buckley, Suzanne M. K., Parker, Alan L., Perocheau, Dany, McKay, Tristan R., Rahim, Ahad A., Howe, Steven J., Waddington, Simon N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352475/
https://www.ncbi.nlm.nih.gov/pubmed/25759840
http://dx.doi.org/10.1155/2015/397879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352475/
https://www.ncbi.nlm.nih.gov/pubmed/25759840
http://dx.doi.org/10.1155/2015/397879

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