Cargando…

Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery

Following fetal or neonatal gene transfer in mice and other species immune tolerance of the transgenic protein is frequently observed; however the underlying mechanisms remain largely undefined. In this study fetal and neonatal BALB/c mice received adenovirus vector to deliver human factor IX (hFIX)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nivsarkar, Megha S., Buckley, Suzanne M. K., Parker, Alan L., Perocheau, Dany, McKay, Tristan R., Rahim, Ahad A., Howe, Steven J., Waddington, Simon N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352475/ https://www.ncbi.nlm.nih.gov/pubmed/25759840 http://dx.doi.org/10.1155/2015/397879

Ejemplares similares

Perinatal Gene Transfer to the Liver
por: McKay, Tristan R, et al.
Publicado: (2011)

In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters
por: Buckley, Suzanne M. K., et al.
Publicado: (2015)

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy
por: Vink, Conrad A., et al.
Publicado: (2017)

Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice
por: Delhove, Juliette M. K. M., et al.
Publicado: (2017)

Correction: Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
por: Plotegher, Nicoletta, et al.
Publicado: (2020)

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
por: Plotegher, Nicoletta, et al.
Publicado: (2019)

Continual conscious bioluminescent imaging in freely moving somatotransgenic mice
por: Karda, Rajvinder, et al.
Publicado: (2017)

Role of antigen-specific regulatory CD4(+)CD25(+) T cells in tolerance induction after neonatal IP administration of AAV-hF.IX
por: Shi, Y, et al.
Publicado: (2013)

TGF-β1 maintains suppressor function and Foxp3 expression in CD4(+)CD25(+) regulatory T cells
por: Marie, Julien C., et al.
Publicado: (2005)

Regulation of CD4(+)CD8(−)CD25(+) and CD4(+)CD8(+)CD25(+) T cells by gut microbiota in chicken
por: Lee, In Kyu, et al.
Publicado: (2018)

Generation of light-producing somatic-transgenic mice using adeno-associated virus vectors
por: Karda, Rajvinder, et al.
Publicado: (2020)

High-frequency and activation of CD4(+)CD25(+) T cells maintain persistent immunotolerance induced by congenital ALV-J infection
por: He, Shuhai, et al.
Publicado: (2021)

Phenotypic, Functional, and Gene Expression Profiling of Peripheral CD45RA+ and CD45RO+ CD4+CD25+CD127(low) Treg Cells in Patients With Chronic Rheumatoid Arthritis
por: Walter, Gina J., et al.
Publicado: (2015)

Changes in Reactivity In Vitro of CD4(+)CD25(+) and CD4(+)CD25(−) T Cell Subsets in Transplant Tolerance
por: Hall, Bruce M., et al.
Publicado: (2017)

Immunologic Self-Tolerance Maintained by Cd25(+)Cd4(+)Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
por: Takahashi, Takeshi, et al.
Publicado: (2000)

Perinatal systemic gene delivery using adeno-associated viral vectors
por: Karda, Rajvinder, et al.
Publicado: (2014)

Auditory stimulation of opera music induced prolongation of murine cardiac allograft survival and maintained generation of regulatory CD4(+)CD25(+ )cells
por: Uchiyama, Masateru, et al.
Publicado: (2012)

CD4(+)CD25(+) Cells Are Essential for Maintaining Immune Tolerance in Chickens Inoculated with Bovine Serum Albumin at the Late Stage of Embryonic Development
por: Yu, Xiaoxue, et al.
Publicado: (2020)

Conversion of CD4(+) CD25(−) cells into CD4(+) CD25(+) regulatory T cells in vivo requires B7 costimulation, but not the thymus
por: Liang, Shuang, et al.
Publicado: (2005)

CD4(+)CD25(+)CD127(−) and CD4(+)CD25(+)Foxp3(+) Regulatory T Cell Subsets in Mediating Autoimmune Reactivity in Systemic Lupus Erythematosus Patients
por: Żabińska, Marcelina, et al.
Publicado: (2016)

Hepatitis B envelope antigen increases Tregs by converting CD4+CD25(-) T cells into CD4(+)CD25(+)Foxp3(+) Tregs
por: Tang, Rui, et al.
Publicado: (2020)

MAIT cells boost adenovirus-induced CD8(+) T cells
por: Flemming, Alexandra
Publicado: (2021)

CD4:CD8 ratio in children with perinatally acquired HIV‐1 infection
por: Seers, T, et al.
Publicado: (2018)

Genetic Incorporation of Human Metallothionein into the Adenovirus Protein IX for Non-Invasive SPECT Imaging
por: Mathis, J. Michael, et al.
Publicado: (2011)

Certified Professionals: Cd4(+)Cd25(+) Suppressor T Cells
por: Shevach, Ethan M.
Publicado: (2001)

CD4(+)CD25(+) T regulatory cells in renal transplantation
por: Cheung, Jason, et al.
Publicado: (2022)

Expression of CD25 fluctuates in the leukemia-initiating cell population of CD25-positive AML
por: Kageyama, Yuki, et al.
Publicado: (2018)

HSP70 Enhances Immunosuppressive Function of CD4(+)CD25(+)FoxP3(+) T Regulatory Cells and Cytotoxicity in CD4(+)CD25(−) T Cells
por: Wachstein, Julian, et al.
Publicado: (2012)

Human CD4(+)CD25(+)CD226(-) Tregs Demonstrate Increased Purity, Lineage Stability, and Suppressive Capacity Versus CD4(+)CD25(+)CD127(lo/-) Tregs for Adoptive Cell Therapy
por: Brown, Matthew E., et al.
Publicado: (2022)

Conversion of Peripheral CD4(+)CD25(−) Naive T Cells to CD4(+)CD25(+) Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3
por: Chen, WanJun, et al.
Publicado: (2003)

In vitro effects of meloxicam on the number, Foxp3 expression, production of selected cytokines, and apoptosis of bovine CD25+CD4+ and CD25-CD4+ cells
por: Maślanka, Tomasz, et al.
Publicado: (2013)

CD73 Is Dispensable for the Regulation of Inflationary CD8(+) T-Cells after Murine Cytomegalovirus Infection and Adenovirus Immunisation
por: Sims, Stuart, et al.
Publicado: (2014)

Regulatory CD4(+)CD25(+) T Cells Restrict Memory CD8(+) T Cell Responses
por: Kursar, Mischo, et al.
Publicado: (2002)

Argininosuccinic aciduria fosters neuronal nitrosative stress reversed by Asl gene transfer
por: Baruteau, Julien, et al.
Publicado: (2018)

CD4+CD25(high), CD8+CD28– cells and thyroid autoantibodies in breast cancer patients
por: Biylgi, Oğuz, et al.
Publicado: (2014)

Construction of a pIX-modified Adenovirus Vector Able to Effectively Bind to Nanoantibodies for Targeting
por: Garas, M. N., et al.
Publicado: (2014)

Enhanced transduction of CAR-negative cells by protein IX-gene deleted adenovirus 5 vectors
por: de Vrij, Jeroen, et al.
Publicado: (2011)

Ascending Vaginal Infection Using Bioluminescent Bacteria Evokes Intrauterine Inflammation, Preterm Birth, and Neonatal Brain Injury in Pregnant Mice
por: Suff, Natalie, et al.
Publicado: (2018)

Downregulation of CD4+LAP+ and CD4+CD25+ Regulatory T Cells in Acute Coronary Syndromes
por: Lin, Ying-zhong, et al.
Publicado: (2013)

CD4(+)CD25(high)CD127(-) regulatory T-cells in COPD: smoke and drugs effect
por: Chiappori, Alessandra, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_60i3b7b2go3p9f31jdcn1hea46