DNA Damage and Inhibition of Akt Pathway in MCF-7 Cells and Ehrlich Tumor in Mice Treated with 1,4-Naphthoquinones in Combination with Ascorbate

The aim of this study was to enhance the understanding of the antitumor mechanism of 1,4-naphthoquinones and ascorbate. Juglone, phenylaminonaphthoquinone-7, and 9 (Q7/Q9) were evaluated for effects on CT-DNA and DNA of cancer cells. Evaluations in MCF-7 cells are DNA damage, ROS levels, viability,...

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Detalles Bibliográficos
Autores principales: Ourique, Fabiana, Kviecinski, Maicon R., Felipe, Karina B., Correia, João Francisco Gomes, Farias, Mirelle S., Castro, Luiza S. E. P. W., Grinevicius, Valdelúcia M. A. S., Valderrama, Jaime, Rios, David, Benites, Julio, Buc Calderon, Pedro, Pedrosa, Rozangela Curi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352476/
https://www.ncbi.nlm.nih.gov/pubmed/25793019
http://dx.doi.org/10.1155/2015/495305

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