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Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study

Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antio...

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Autores principales: Sirivarasai, Jintana, Kaojarern, Sukhumpun, Chanprasertyothin, Suwannee, Panpunuan, Pachara, Petchpoung, Krittaya, Tatsaneeyapant, Aninthita, Yoovathaworn, Krongtong, Sura, Thunyachai, Kaojarern, Sming, Sritara, Piyamit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352505/
https://www.ncbi.nlm.nih.gov/pubmed/25793211
http://dx.doi.org/10.1155/2015/856319
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author Sirivarasai, Jintana
Kaojarern, Sukhumpun
Chanprasertyothin, Suwannee
Panpunuan, Pachara
Petchpoung, Krittaya
Tatsaneeyapant, Aninthita
Yoovathaworn, Krongtong
Sura, Thunyachai
Kaojarern, Sming
Sritara, Piyamit
author_facet Sirivarasai, Jintana
Kaojarern, Sukhumpun
Chanprasertyothin, Suwannee
Panpunuan, Pachara
Petchpoung, Krittaya
Tatsaneeyapant, Aninthita
Yoovathaworn, Krongtong
Sura, Thunyachai
Kaojarern, Sming
Sritara, Piyamit
author_sort Sirivarasai, Jintana
collection PubMed
description Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension.
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spelling pubmed-43525052015-03-19 Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study Sirivarasai, Jintana Kaojarern, Sukhumpun Chanprasertyothin, Suwannee Panpunuan, Pachara Petchpoung, Krittaya Tatsaneeyapant, Aninthita Yoovathaworn, Krongtong Sura, Thunyachai Kaojarern, Sming Sritara, Piyamit Biomed Res Int Research Article Lead has been linked to the development of hypertension via oxidative stress. Catalase plays an important role in the disposal of hydrogen peroxide in erythrocyte and its activity was determined by CAT gene. The aims of this study were to investigate (1) the association between blood levels of antioxidant markers such as catalase, superoxide dismutase, glutathione, glutathione peroxidase, oxidative stress-marker (malondialdehyde), and blood lead level and (2) the influence of genetic polymorphism of CAT gene (rs769217) on change in blood pressure in general population of EGAT study project. This is a cross-sectional study of 332 normotensive, 432 prehypertensive, and 222 hypertensive male subjects. Hypertensive subjects had significantly higher blood lead level (5.28 μg/dL) compared to normotensive (4.41 μg/dL) and prehypertensive (4.55 μg/dL) subjects (P < 0.05). These significant findings are also found in MDA levels. Moreover, individuals with TT genotype in hypertensive group had significantly higher blood lead and MDA levels (6.06 μg/dL and 9.67 μmol/L) than those with CC genotype (5.32 μg/dL and 8.31 μmol/L, P < 0.05). Our findings suggested that decreased blood catalase activity in this polymorphism together with low level lead exposure induced lipid peroxidation may be responsible for hypertension. Hindawi Publishing Corporation 2015 2015-02-22 /pmc/articles/PMC4352505/ /pubmed/25793211 http://dx.doi.org/10.1155/2015/856319 Text en Copyright © 2015 Jintana Sirivarasai et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sirivarasai, Jintana
Kaojarern, Sukhumpun
Chanprasertyothin, Suwannee
Panpunuan, Pachara
Petchpoung, Krittaya
Tatsaneeyapant, Aninthita
Yoovathaworn, Krongtong
Sura, Thunyachai
Kaojarern, Sming
Sritara, Piyamit
Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
title Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
title_full Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
title_fullStr Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
title_full_unstemmed Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
title_short Environmental Lead Exposure, Catalase Gene, and Markers of Antioxidant and Oxidative Stress Relation to Hypertension: An Analysis Based on the EGAT Study
title_sort environmental lead exposure, catalase gene, and markers of antioxidant and oxidative stress relation to hypertension: an analysis based on the egat study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352505/
https://www.ncbi.nlm.nih.gov/pubmed/25793211
http://dx.doi.org/10.1155/2015/856319
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