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Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification
BACKGROUND: The hepatic resection for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) which is not uncommon at clinic continues to be debated. Our study introduced a novel classification of HCC with PVTT and compared the outcomes of surgical treatment between different groups....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352541/ https://www.ncbi.nlm.nih.gov/pubmed/25889711 http://dx.doi.org/10.1186/s12957-015-0493-x |
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author | Xu, Jiang-feng Liu, Xi-yu Wang, Shuai Wen, Huai-xi |
author_facet | Xu, Jiang-feng Liu, Xi-yu Wang, Shuai Wen, Huai-xi |
author_sort | Xu, Jiang-feng |
collection | PubMed |
description | BACKGROUND: The hepatic resection for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) which is not uncommon at clinic continues to be debated. Our study introduced a novel classification of HCC with PVTT and compared the outcomes of surgical treatment between different groups. METHODS: From January 2008 to December 2012, a total of 56 cases of HCC with PVTT underwent liver resection combined with thrombectomy. Clinical pathological features and surgical data of these patients were retrospectively studied. The patients were divided into two groups. Cumulative overall and disease-free survival curves of the patients were compared according to different groups. RESULTS: Sixteen patients (28.6%) belonging to group A were compared to 40 patients (71.4%) belonging to group B. The rates of capsular formation and tumor number showed differences between the two groups (P = 0.047, P = 0.032). Group A had more liver cirrhosis than group B (P = 0.047). The patients with large blood loss (≥1,000) were more in group A, as well. There was no significant difference in complications between the two groups except the ascites (P = 0.028). The 1-year overall survival rate of group A after liver resection was 31.5%. The 1-, 3-, and 5-year overall survival rates of group B were 62.3%, 16.1%, and 5.2%, respectively. For further study, group B had significantly better overall survival than group A (P = 0.033). Group A had significantly higher incidence of recurrence than group B (P = 0.021). CONCLUSIONS: Liver resection combined with thrombectomy for HCC with PVTT can get better outcome in the HCC patients with PVTT involving only one branch (left/right) of portal vein (group B) compared to patients with PVTT involving the main portal vein trunk or both the left and right portal veins (group A). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-015-0493-x) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4352541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43525412015-03-09 Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification Xu, Jiang-feng Liu, Xi-yu Wang, Shuai Wen, Huai-xi World J Surg Oncol Research BACKGROUND: The hepatic resection for hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) which is not uncommon at clinic continues to be debated. Our study introduced a novel classification of HCC with PVTT and compared the outcomes of surgical treatment between different groups. METHODS: From January 2008 to December 2012, a total of 56 cases of HCC with PVTT underwent liver resection combined with thrombectomy. Clinical pathological features and surgical data of these patients were retrospectively studied. The patients were divided into two groups. Cumulative overall and disease-free survival curves of the patients were compared according to different groups. RESULTS: Sixteen patients (28.6%) belonging to group A were compared to 40 patients (71.4%) belonging to group B. The rates of capsular formation and tumor number showed differences between the two groups (P = 0.047, P = 0.032). Group A had more liver cirrhosis than group B (P = 0.047). The patients with large blood loss (≥1,000) were more in group A, as well. There was no significant difference in complications between the two groups except the ascites (P = 0.028). The 1-year overall survival rate of group A after liver resection was 31.5%. The 1-, 3-, and 5-year overall survival rates of group B were 62.3%, 16.1%, and 5.2%, respectively. For further study, group B had significantly better overall survival than group A (P = 0.033). Group A had significantly higher incidence of recurrence than group B (P = 0.021). CONCLUSIONS: Liver resection combined with thrombectomy for HCC with PVTT can get better outcome in the HCC patients with PVTT involving only one branch (left/right) of portal vein (group B) compared to patients with PVTT involving the main portal vein trunk or both the left and right portal veins (group A). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12957-015-0493-x) contains supplementary material, which is available to authorized users. BioMed Central 2015-02-28 /pmc/articles/PMC4352541/ /pubmed/25889711 http://dx.doi.org/10.1186/s12957-015-0493-x Text en © Xu et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Xu, Jiang-feng Liu, Xi-yu Wang, Shuai Wen, Huai-xi Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
title | Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
title_full | Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
title_fullStr | Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
title_full_unstemmed | Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
title_short | Surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
title_sort | surgical treatment for hepatocellular carcinoma with portal vein tumor thrombus: a novel classification |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352541/ https://www.ncbi.nlm.nih.gov/pubmed/25889711 http://dx.doi.org/10.1186/s12957-015-0493-x |
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