Predicting functional and regulatory divergence of a drug resistance transporter gene in the human malaria parasite

BACKGROUND: The paradigm of resistance evolution to chemotherapeutic agents is that a key coding mutation in a specific gene drives resistance to a particular drug. In the case of resistance to the anti-malarial drug chloroquine (CQ), a specific mutation in the transporter pfcrt is associated with r...

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Detalles Bibliográficos
Autores principales: Siwo, Geoffrey H, Tan, Asako, Button-Simons, Katrina A, Samarakoon, Upeka, Checkley, Lisa A, Pinapati, Richard S, Ferdig, Michael T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352545/
https://www.ncbi.nlm.nih.gov/pubmed/25765049
http://dx.doi.org/10.1186/s12864-015-1261-6

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