Genomic landscape of pediatric adrenocortical tumors

Pediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyze 37 adrenocortical tumors (ACTs) by whole genome, whole exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal...

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Detalles Bibliográficos
Autores principales: Pinto, Emilia M., Chen, Xiang, Easton, John, Finkelstein, David, Liu, Zhifa, Pounds, Stanley, Rodriguez-Galindo, Carlos, Lund, Troy C., Mardis, Elaine R., Wilson, Richard K., Boggs, Kristy, Yergeau, Donald, Cheng, Jinjun, Mulder, Heather L., Manne, Jayanthi, Jenkins, Jesse, Mastellaro, Maria J., Figueiredo, Bonald C., Dyer, Michael A., Pappo, Alberto, Zhang, Jinghui, Downing, James R., Ribeiro, Raul C., Zambetti, Gerard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352712/
https://www.ncbi.nlm.nih.gov/pubmed/25743702
http://dx.doi.org/10.1038/ncomms7302

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