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Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and transcription

We have previously demonstrated that in Saccharomyces cerevisiae replication, checkpoint inactivation via a mec1 mutation leads to chromosome breakage at replication forks initiated from virtually all origins after transient exposure to hydroxyurea (HU), an inhibitor of ribonucleotide reductase. Her...

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Detalles Bibliográficos
Autores principales:	Hoffman, Elizabeth A., McCulley, Andrew, Haarer, Brian, Arnak, Remigiusz, Feng, Wenyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352882/ https://www.ncbi.nlm.nih.gov/pubmed/25609572 http://dx.doi.org/10.1101/gr.180497.114

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