A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆

An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and h...

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Autores principales: Ma, Xuntai, Tang, Yong, Lv, Yang, Cheng, Oumei, Yan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Technique and Method: Brain Injury and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353098/
https://www.ncbi.nlm.nih.gov/pubmed/25806067
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.04.005
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author Ma, Xuntai
Tang, Yong
Lv, Yang
Cheng, Oumei
Yan, Yong
author_facet Ma, Xuntai
Tang, Yong
Lv, Yang
Cheng, Oumei
Yan, Yong
author_sort Ma, Xuntai
collection PubMed
description An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume.
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spelling pubmed-43530982015-03-24 A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆ Ma, Xuntai Tang, Yong Lv, Yang Cheng, Oumei Yan, Yong Neural Regen Res Technique and Method: Brain Injury and Neuroregeneration An animal model of cortical dysplasia was established through X-ray irradiation induced subcortical heterotopic nodules in rats. Transmission electron microscopy detection of the ultrastructure and the stereology examination showed that there was a significant decrease in cerebral white matter and hippocampal volume, the total volume, volume density, length density and total length of the myelinated fibers in the white matter of cortical dysplasia rats. Subcortical heterotopic nodules of the hippocampal CA1 region and synaptic number density in the CA3 region were reduced compared with normal rats. Our experimental findings indicate that erosed subcortical heterotopic nodules, decreased total length of myelinated nerve fibers and demyelination directly lead to a reduction of white matter volume. Medknow Publications & Media Pvt Ltd 2012-02-05 /pmc/articles/PMC4353098/ /pubmed/25806067 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.04.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technique and Method: Brain Injury and Neuroregeneration
Ma, Xuntai
Tang, Yong
Lv, Yang
Cheng, Oumei
Yan, Yong
A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
title A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
title_full A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
title_fullStr A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
title_full_unstemmed A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
title_short A quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
title_sort quantitative study on changes of the myelinated fibers in the cerebral cortex of cortical dysplasia rats☆
topic Technique and Method: Brain Injury and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353098/
https://www.ncbi.nlm.nih.gov/pubmed/25806067
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.04.005
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