Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆

A rat model of Parkinson's disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks,...

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Autores principales: Li, Yinghong, Wu, Zhengzhi, Gao, Xiaowei, Zhu, Qingwei, Jin, Yu, Wu, Anmin, Huang, Andrew C. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353108/
https://www.ncbi.nlm.nih.gov/pubmed/25767493
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.001
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author Li, Yinghong
Wu, Zhengzhi
Gao, Xiaowei
Zhu, Qingwei
Jin, Yu
Wu, Anmin
Huang, Andrew C. J.
author_facet Li, Yinghong
Wu, Zhengzhi
Gao, Xiaowei
Zhu, Qingwei
Jin, Yu
Wu, Anmin
Huang, Andrew C. J.
author_sort Li, Yinghong
collection PubMed
description A rat model of Parkinson's disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson's disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson's disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system.
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spelling pubmed-43531082015-03-12 Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆ Li, Yinghong Wu, Zhengzhi Gao, Xiaowei Zhu, Qingwei Jin, Yu Wu, Anmin Huang, Andrew C. J. Neural Regen Res Research and Report: Traditional Chinese Medicine and Neuroregeneration A rat model of Parkinson's disease was induced by injecting lactacystin stereotaxically into the left mesencephalic ventral tegmental area and substantia nigra pars compacta. After rats were intragastrically perfused with Anchanling, a Chinese medicine, mainly composed of magnolol, for 5 weeks, when compared with Parkinson's disease model rats, tyrosine hydroxylase expression was increased, α-synuclein and ubiquitin expression was decreased, substantia nigra cell apoptosis was reduced, and apomorphine-induced rotational behavior was improved. Results suggested that Anchanling can ameliorate Parkinson's disease pathology possibly by enhancing degradation activity of the ubiquitin-proteasome system. Medknow Publications & Media Pvt Ltd 2012-01-25 /pmc/articles/PMC4353108/ /pubmed/25767493 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.001 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Traditional Chinese Medicine and Neuroregeneration
Li, Yinghong
Wu, Zhengzhi
Gao, Xiaowei
Zhu, Qingwei
Jin, Yu
Wu, Anmin
Huang, Andrew C. J.
Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆
title Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆
title_full Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆
title_fullStr Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆
title_full_unstemmed Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆
title_short Anchanling reduces pathology in a lactacystin- induced Parkinson's disease model☆
title_sort anchanling reduces pathology in a lactacystin- induced parkinson's disease model☆
topic Research and Report: Traditional Chinese Medicine and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353108/
https://www.ncbi.nlm.nih.gov/pubmed/25767493
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.001
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