Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆

Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential de...

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Autores principales: Gong, Zheng, Yang, Lijuan, Tang, Hongmei, Pan, Rui, Xie, Sai, Guo, Luyan, Wang, Junbin, Deng, Qinyin, Xiong, Guoyin, Xing, Yanyan, Dong, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353109/
https://www.ncbi.nlm.nih.gov/pubmed/25767494
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.002
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author Gong, Zheng
Yang, Lijuan
Tang, Hongmei
Pan, Rui
Xie, Sai
Guo, Luyan
Wang, Junbin
Deng, Qinyin
Xiong, Guoyin
Xing, Yanyan
Dong, Jun
author_facet Gong, Zheng
Yang, Lijuan
Tang, Hongmei
Pan, Rui
Xie, Sai
Guo, Luyan
Wang, Junbin
Deng, Qinyin
Xiong, Guoyin
Xing, Yanyan
Dong, Jun
author_sort Gong, Zheng
collection PubMed
description Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.
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spelling pubmed-43531092015-03-12 Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆ Gong, Zheng Yang, Lijuan Tang, Hongmei Pan, Rui Xie, Sai Guo, Luyan Wang, Junbin Deng, Qinyin Xiong, Guoyin Xing, Yanyan Dong, Jun Neural Regen Res Research and Report: Traditional Chinese Medicine and Neuroregeneration Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury. Medknow Publications & Media Pvt Ltd 2012-01-25 /pmc/articles/PMC4353109/ /pubmed/25767494 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.002 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Traditional Chinese Medicine and Neuroregeneration
Gong, Zheng
Yang, Lijuan
Tang, Hongmei
Pan, Rui
Xie, Sai
Guo, Luyan
Wang, Junbin
Deng, Qinyin
Xiong, Guoyin
Xing, Yanyan
Dong, Jun
Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆
title Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆
title_full Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆
title_fullStr Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆
title_full_unstemmed Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆
title_short Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats☆
title_sort protective effects of curcumin against human immunodeficiency virus 1 gp120 v3 loop-induced neuronal injury in rats☆
topic Research and Report: Traditional Chinese Medicine and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353109/
https://www.ncbi.nlm.nih.gov/pubmed/25767494
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.002
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