Cargando…

Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★

The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7....

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Wentao, Wang, Qian, Yan, Yongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353112/
https://www.ncbi.nlm.nih.gov/pubmed/25767497
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.005
_version_ 1782360556817088512
author Fan, Wentao
Wang, Qian
Yan, Yongmei
author_facet Fan, Wentao
Wang, Qian
Yan, Yongmei
author_sort Fan, Wentao
collection PubMed
description The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac.
format Online
Article
Text
id pubmed-4353112
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-43531122015-03-12 Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★ Fan, Wentao Wang, Qian Yan, Yongmei Neural Regen Res Research and Report: Traditional Chinese Medicine and Neuroregeneration The present study established a rat model of post-stroke depression using incomplete ischemia induced by unilateral carotid artery ligation in combination with solitary raising and subcutaneous injection of a small dose of reserpine. After intragastric perfusion with 45 mg/100 g, 15 mg/100 g, and 7.5 mg/100 g of Xingnao Jieyu for 7, 14 and 21 days, neuronal morphology in the frontal lobe and hippocampus was improved, depression state and voluntary behaviors were also effectively improved in rats with post-stroke depression. Moreover, the effects of Xingnao Jieyu at a dose of 45 and 15 mg/100 g were similar to the traditional antidepressant Prozac. Medknow Publications & Media Pvt Ltd 2012-01-25 /pmc/articles/PMC4353112/ /pubmed/25767497 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Traditional Chinese Medicine and Neuroregeneration
Fan, Wentao
Wang, Qian
Yan, Yongmei
Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
title Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
title_full Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
title_fullStr Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
title_full_unstemmed Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
title_short Influence of Xingnao Jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
title_sort influence of xingnao jieyu capsule on hippocampal and frontal lobe neuronal growth in a rat model of post-stroke depression★
topic Research and Report: Traditional Chinese Medicine and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353112/
https://www.ncbi.nlm.nih.gov/pubmed/25767497
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.005
work_keys_str_mv AT fanwentao influenceofxingnaojieyucapsuleonhippocampalandfrontallobeneuronalgrowthinaratmodelofpoststrokedepression
AT wangqian influenceofxingnaojieyucapsuleonhippocampalandfrontallobeneuronalgrowthinaratmodelofpoststrokedepression
AT yanyongmei influenceofxingnaojieyucapsuleonhippocampalandfrontallobeneuronalgrowthinaratmodelofpoststrokedepression