Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★

This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus i...

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Autores principales: Dong, Zhijun, Tao, Xiangyi, Fu, Xiaoxiao, Wang, Haibin, Wang, Donghua, Zhang, Tiemin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Research and Report: Traditional Chinese Medicine and Neuroregeneration
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353115/
https://www.ncbi.nlm.nih.gov/pubmed/25767500
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.008
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author Dong, Zhijun
Tao, Xiangyi
Fu, Xiaoxiao
Wang, Haibin
Wang, Donghua
Zhang, Tiemin
author_facet Dong, Zhijun
Tao, Xiangyi
Fu, Xiaoxiao
Wang, Haibin
Wang, Donghua
Zhang, Tiemin
author_sort Dong, Zhijun
collection PubMed
description This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy.
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spelling pubmed-43531152015-03-12 Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★ Dong, Zhijun Tao, Xiangyi Fu, Xiaoxiao Wang, Haibin Wang, Donghua Zhang, Tiemin Neural Regen Res Research and Report: Traditional Chinese Medicine and Neuroregeneration This study sought to investigate the effects of Purendan superfine powder comprised of Momordica charantia, Radix Ginseng, and Radix Salviae Miltiorrhiae on neuronal apoptosis and expression of bcl-2, bax, and caspase-3, which are retinal apoptosis-associated factors in rats with diabetes mellitus induced by continuous intraperitoneal injection of streptozotocin. The results showed that Purendan superfine powder could upregulate the expression of bcl-2 protein and mRNA, and downregulate the expression of bax and caspase-3 in the retina of diabetes mellitus rats. In addition, Purendan superfine powder was shown to reduce the number of apoptotic neurons. Our experimental findings indicate that Purendan superfine powder can inhibit neuronal apoptosis in the retina of diabetes mellitus rats and has protective effects on diabetic retinopathy. Medknow Publications & Media Pvt Ltd 2012-01-25 /pmc/articles/PMC4353115/ /pubmed/25767500 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.008 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report: Traditional Chinese Medicine and Neuroregeneration
Dong, Zhijun
Tao, Xiangyi
Fu, Xiaoxiao
Wang, Haibin
Wang, Donghua
Zhang, Tiemin
Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
title Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
title_full Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
title_fullStr Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
title_full_unstemmed Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
title_short Protective effects of Purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
title_sort protective effects of purendan superfine powder on retinal neuron apoptosis in a rat model of type 2 diabetes mellitus★
topic Research and Report: Traditional Chinese Medicine and Neuroregeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353115/
https://www.ncbi.nlm.nih.gov/pubmed/25767500
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.03.008
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