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Pharmacological inhibition of Polo-like kinase 1 (PLK1) by BI-2536 decreases the viability and survival of hamartin and tuberin deficient cells via induction of apoptosis and attenuation of autophagy

The mechanistic target of rapamycin complex 1 (mTORC1) increases translation, cell size and angiogenesis, and inhibits autophagy. mTORC1 is negatively regulated by hamartin and tuberin, the protein products of the tumor suppressors TSC1 and TSC2 that are mutated in Tuberous Sclerosis Complex (TSC) a...

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Detalles Bibliográficos
Autores principales:	Valianou, Matthildi, Cox, Andrew M, Pichette, Benjamin, Hartley, Shannon, Paladhi, Unmesha Roy, Astrinidis, Aristotelis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353234/ https://www.ncbi.nlm.nih.gov/pubmed/25565629 http://dx.doi.org/10.4161/15384101.2014.986394

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